Transkranielle Pulsstimulation (TPS) – Studien, Poster und Literatur

Forschung und Studien: Transkranielle Pulsstimulation bei Alzheimer-Demenz und anderen Indikationen

Die Stoßwellen-Therapie Transkranielle Pulsstimulation (TPS) in den Bereichen Neurologie und Psychiatrie wird seit rund 30 Jahren klinisch in Studien erforscht. Sie gehört zu jenen nicht-invasiven Hirnstimulations-Methoden (non invasive brain stimulation – NIBS), deren internationales Forschungsaufkommen besonders stark expandiert.

Neben weiterer Grundlagenforschung und laufenden Untersuchungen zur Transkraniellen Pulsstimulation (TPS) bei leichter, mittelgradiger sowie schwerer Alzheimer-Erkrankung, sind auch die Behandlung von Morbus Parkinson, Depressionen, Long Covid und Post Covid (post-acute sequelae of COVID-19 / PASC), Fatigue, Autismus, Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) und andere Indikationen Gegenstand wissenschaftlicher Forschung.

Alle bis dato publizierten Studien und Arbeiten sind nachfolgend als Listen mit der Möglichkeit des Downloads als pdf bzw. mit direkten Links zu den Publikationen zu finden.

Zahlreiche neue Studien, Pilot-Projekte, Anwendungsbeobachtungen und multizentrische Untersuchungen befinden sich in Arbeit. Sie werden dazu beitragen, Nutzen und Sicherheit für die Patient:innen und damit auch die gesellschaftliche Relevanz der TPS weiterhin zu belegen und zu festigen.

Transkranielle Pulsstimulation (TPS) – Aktuelle Studien:

Titel	Beschreibung	Jahr
Non-invasive sound wave brain stimulation with Transcranial Pulse Stimulation (TPS) improves neuropsychiatric symptoms in Alzheimer’s disease	Shinzato GT, Assone T, Sandler PC, Pacheco-Barrios K, Fregni F, Radanovic M, Forlenza OV, Battistella LR, Brain Stimulation (2024), doi: https://doi.org/10.1016/j.brs.2024.03.007	2024
Novel ultrasound neuromodulation therapy with transcranial pulse stimulation (TPS) in Parkinson’s disease: a first retrospective analysis	Sarah Osou ¹ · Sonja Radjenovic ¹ · Lena Bender ¹ · Martin Gaal ¹ · Anna Zettl ^1,2 · Gregor Dörl ¹ · Eva Matt ¹ · Roland Beisteiner ¹ ( ¹ Department of Neurology, Medical University of Vienna \| ² Department of Pediatrics and Adolescent Medicine, Medical University of Vienna)	2023
Effects of transcranial pulse stimulation (TPS) on adults with symptoms of depression – a Pilot Randomized Controlled Trial	Teris Cheung^1*, Lok Yi Chiu¹ , Tim Man Ho Li² , Yuen Shan Ho¹ , Georg Kranz³ , Kenneth Fong³ , Sau Fong Leung¹ , Simon Ching Lam⁴ , Wing Fai Yeung¹ , Joyce Lam¹ , Kwan Hin Fong¹ , Roland Beisteiner⁵ , Yu Tao Xiang⁶ , Calvin Cheng⁷ ( ¹ School of Nursing, the Hong Kong Polytechnic University, Hong Kong SAR, China \| ² Department of Psychiatry, the Chinese University of Hong Kong, Hong Kong SAR, China \| ³ Department of Rehabilitation Sciences, the Hong Kong Polytechnic University, Hong Kong SAR, China \| ⁴ School of Nursing, Tung Wah College, Hong Kong SAR, China \| ⁵ Department of Neurology, Medical University of Vienna, Austria \| ⁶ Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China \| ⁷ Department of Psychiatry, University of Hong Kong, Hong Kong SAR, China )	2023
Effects of transcranial pulse stimulation on autism spectrum disorder: a double-blind, randomized, sham-controlled trial	Teris Cheung,^1,2 Tim Man Ho Li,³ Joyce Yuen Ting Lam,¹ Kwan Hin Fong,¹ Lok Yi Chiu,¹ Yuen Shan Ho,¹ Andy Choi-Yeung Tse,⁴ Cheng-Ta Li,⁵ Calvin Pak-Wing Cheng⁶ and Roland Beisteiner⁷ — ( ¹ School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China \| ² The Mental Health Research Centre, The Hong Kong Polytechnic University, Hong Kong SAR, China \| ³ Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China \| ⁴ Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong SAR, China \| ⁵ Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan \| ⁶ Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China \| ⁷ Department of Neurology, Medical University of Vienna, Wien 1090, Austria ), BRAIN COMMUNICATIONS 2023; https://academic.oup.com/braincomms/article/5/5/fcad226/7246015	2023
Effect of Transcranial Pulse Stimulation for the Treatment of Alzheimer´s Disease and its Related Symptoms	Fernández-Castaño R, Fernández-Blázquez MÁ, Echevarría Fernández I, Cabrera-Freitag M, Freitag K., 2023; 20(4):244-249: DOI 10.2174/1567205020666230727102025. PMID: 37497687.	2023
Transcranial pulse stimulation in the treatment of mild neurocognitive disorders	Fong TKH, Cheung T, Ngan STJ, et al. In: Ann Clin Transl Neurol. 2023 Aug 21: DOI 10.1002/acn3.51882	2023
Transcranial Pulse Stimulation in Alzheimer’s disease	Xinxin Chen, Jiuhong You, Hui Ma, Mei Zhou, Cheng Huang (2023). In: CNS Neuroscience & Therapeutics: DOI 10.1111 / cns.14372	2023
Evaluating the efficacy and safety of TPS on adolescents with attention deficit hyperactivity disorder: Study protocol of a pilot randomized, double-blind, sham-controlled trial	Teris Cheung1,2, Bolton Chau3, Kwan Hin Fong1, Joyce Yuen Ting Lam1, Herman Lo4, Man Ho Li5, Albert Martin Man Chim Li6, Roland Beisteiner7, Sun Lei8, Benjamin K. Yee2,3 and Calvin Pak Wing Cheng9 (2023). In: Frontiers in Neurology: DOI 10.3389 / fneur.2023.1076086	2023
Brain Stimulation by noninvasive Transcranial Pulse Stimulation (TPS) improves cognitive Deficits and Mood in Alzheimer’s Disease	Sprick U, Köhne M. (2022). In: Proceedings of the International Conference on Electrical, Computer, Communications and Mechatronics Engineering (ICECCME), 16-18 Nov 2022, Maldives	2022
Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol	Cheung T, Ho YS, Fong KH, Lam YTJ, Li MH, Tse AC, Li CT, Cheng CP, Beisteiner, R. Int J Environ Res Public Health. 2022 Nov 24;19(23) : 15614. DOI: 10.3390/ijerph192315614. PMID: 36497688; PMCID: PMC9737330	2022
Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer’s patients	Cont C, Stute N, Galli A, Schulte C, Logmin K, Trenado C, Wojtecki L. Front Neurol. 2022 Sep 14;13:948204. DOI: 10.3389 / fneur.2022.948204. PMID: 36188380; PMCID: PMC9515314	2022
Safety of Clinical Ultrasound Neuromodulation	Radjenovic S, Dörl G, Gaal M, Beisteiner R., Brain Sci. 2022, 12, 1277. DOI: 10.3390 / brainsci12101277	2022
Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer’s Disease: A Follow-up fMRI Analysis	Dörl G, Matt E, Beisteiner R. Neurol Therapy, 2022 Sep;11(3):1391-1398 DOI: 10.1007 / s40120-022-00362-8. Epub 2022 May 28. PMID: 35633496; PMCID: PMC9338196	2022
Effects of Transcranial Pulse Stimulation on Young Adults With Symptoms of Depression: A Pilot Randomised Controlled Trial Protocol	Cheung T, Ho J, Yeung J, Fong LS, Fong K, Fong T, Kranz G, Beisteiner R, Cheng C. Frontiers Neurol, 2022 DOI:10.3389 / fneur.2022.861214	2022
Transcranial Pulse Stimulation (TPS) – A highly focused brain stimulation therapy with 3D navigation	Beisteiner R, Hallett M. Clin Neurophysiol. 2022Apr;136:247-248. DOI: 10.1016 / j.clinph.2022.01.127. Epub 2022 Jan 31. PMID:35131146	2022
Transcranial pulse stimulation (TPS) improves depression in AD patients on state-of-the-art treatment	Matt E, Dörl G, Beisteiner R. Alzheimer’s Dementia (N Y). 2022 Feb 10;8(1):e12245. DOI: 10.1002 / trc2.12245	2022
First evidence of long-term effects of transcranial pulse stimulation (TPS) on the human brain	Matt E, Kaindl L, Tenk S, Egger A, Kolarova T, Karahasanović N, Amini A, Arslan A, Sariçiçek K, Weber A, Beisteiner R. J Transl Med. 2022 Jan 15;20(1):26. DOI: 10.1186 / s12967-021-03222-5	2022
Comparison of Transcranial Focused Ultrasound and Transcranial Pulse Stimulation for Neuromodulation: A Computational Study	Truong DQ, Thomas C, Hampstead BM, Datta A. Neuromodulation. 2022 Feb 3:S1094-7159(21)06990-7. DOI: 10.1016 / j.neurom.2021.12.012	2021
Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer’s patients: A follow-up study	Popescu T, Pernet C, Beisteiner R. Alzheimers Dement (N Y). 2021 Feb 25;7(1):e12121. DOI: 10.1002 / trc2.12121	2021
Treating the brain at the speed of sound	Roland Beisteiner, Andres Lozano Brain Stimul. Jul-Aug 2020;13(4):1087-1088. doi: 10.1016 / j.brs.2020.04.020	2020
Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease-A New Navigated Focal Brain Therapy	Beisteiner R, Matt E, Fan C, Baldysiak H, Schönfeld M, Philippi Novak T, Amini A, Aslan T, Reinecke R, Lehrner J, Weber A, Reime U, Goldenstedt C, Marlinghaus E, Hallett M, Lohse-Busch H. Adv Sci (Weinh). 2019 Dec 23;7(3):1902583. DOI: 10.1002 / advs.201902583	2019
Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression Through PERK/ATF4 Signalling Pathway	Bohan Wang, Hongxiu Ning, Amanda B Reed-Maldonado, Jun Zhou, Yajun Ruan, Tie Zhou, Hsun Shuan Wang, Byung Seok Oh, Lia Banie, Guiting Lin, Tom F Lue. Int J Mol Sci. 2017 Feb 16;18(2):433. doi: 10.3390 / ijms18020433	2017

Aktuelle Poster zur Transkraniellen Pulsstimulation (TPS):

Titel	Beschreibung	Jahr
Double-blind clinical trial vs placebo on the impact of Trancranial Pulse Stimulation (TPS) on patients with Post-Covid-19 neurological involvement (Long Covid)	Dr. C Guijarro-Castro¹; MA Fernández Blázquez^1,2, R Sebastián-González¹; Dr. L Fernández-Arana¹, J Martín-Ramírez¹, Dr. Karin Freitag¹ (¹ Department of Cognitive Impairment – Neurology Unit, Clínica DKF, Madrid, Spain. \| ² Department of Biological and Health Psychology, Universidad Autónoma de Madrid, Madrid, Spain)	2024
Transcranial Pulse Stimulation Effects for Alzheimer´s Disease Treatment – Spanish experience with a contol group	Dr. C Guijarro-Castro¹; MA Fernández Blázquez^1,2, R Sebastián-González¹; Dr. L Fernández-Arana¹, J Martín-Ramírez¹, Dr. M Cabrera-Freitag¹, Dr. Karin Freitag¹ (¹ Department of Cognitive Impairment – Neurology Unit, Clínica DKF, Madrid, Spain. \| ² Department of Biological and Health Psychology, Universidad Autónoma de Madrid, Madrid, Spain)	2024
Multimodaler Therapieerfolg bei Lewy-Körper-Demenz mittels Transkranieller Pulsstimulation (TPS): Ein Fallbericht	A. R. Günes¹, N. Eminaga¹, M. Beglau¹, M. Köhne, U. Sprick¹ (¹Alexius / Josef Krankenhaus, Neuss)	2023
Neue Erfolge bei der Behandlung von Patientinnen und Patienten mit Alzheimer-Erkrankung? Die Transkranielle Pulsstimulation (TPS^®)	V. Rößner-Ruff, C. Disque, K. Friedrich, C. Hauser, K. Höffgen, J. Krieger, D. Ludwig, J.T. Michaelsen, M. Missal, C.A. Penkov, O. Rosenthal, H. Stürmann, M. Ziegenbein, D. Clark ( Klinikum Wahrendorff)	2023
Effects of transcranial pulse stimulation (TPS) on adults with symptoms of depression – a Pilot Randomized Controlled Trial	Teris Cheung^1*, Lok Yi Chiu¹ , Tim Man Ho Li² , Yuen Shan Ho¹ , Georg Kranz³ , Kenneth Fong³ , Sau Fong Leung¹ , Simon Ching Lam⁴ , Wing Fai Yeung¹ , Joyce Lam¹ , Kwan Hin Fong¹ , Roland Beisteiner⁵ , Yu Tao Xiang⁶ , Calvin Cheng⁷ ( ¹ School of Nursing, the Hong Kong Polytechnic University, Hong Kong SAR, China \| ² Department of Psychiatry, the Chinese University of Hong Kong, Hong Kong SAR, China \| ³ Department of Rehabilitation Sciences, the Hong Kong Polytechnic University, Hong Kong SAR, China \| ⁴ School of Nursing, Tung Wah College, Hong Kong SAR, China \| ⁵ Department of Neurology, Medical University of Vienna, Austria \| ⁶ Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China \| ⁷ Department of Psychiatry, University of Hong Kong, Hong Kong SAR, China )	2023
Restoration of taste and smell after a Post-Covid 19 induced loss by MRI-tracked Transcranial Pulse Stimulation (TPS): A Case Report	U. Sprick^{1, 2}, N. Eminaga¹, A. R. Günes¹ and M. Köhne¹ ( ¹ Alexius/Josef Hospital, Neuss, Germany \| ² Heinrich-Heine-University of Düsseldorf, Germany )	2023
Transcranial Pulse Stimulation for Alzheimer’s dementia treatment	Barbara Kofler, Sarah Bernsen, Monika Sommer, Catherine Widmann, Ullrich Wüllner ( Dept. of Neurodegenerative Diseases, University Hospital Bonn, Germany )	2023
Long-term effects of nucleus accumbens stimulation through Transcranial Pulse Stimulation in Treatment-resistent Depression: A Case Report	Ali Riza Günes, Nurettin Eminaga, Martin Köhne, Ulrich Sprick ( Alexius/Josef Clinic, Neuss, Germany )	2023
MR-navigated Transcranial Pulsed Shockwave Stimulation (TPS) in Alzheimer‘s patients: Enough Evidence for Clinical use?	Lars Wojtecki^1,2 with Celine Cont^1,2, Jessica Schirmeisen¹, Nathalie Stute¹, Anastasia Galli¹ ( ¹ Clinic for Neurology and Neurorehabilitation, Hospital zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf, Kempen, Germany \| ² Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany )	2023
Transcranial Pulse Stimulation (TPS) in Alzheimer‘s: Long term retrospective group data and individual patient histories	Lars Wojtecki^1,2 with Celine Cont^1,2, Jessica Schirmeisen¹, Nathalie Stute¹, Anastasia Galli¹ ( ¹ Clinic for Neurology and Neurorehabilitation, Hospital zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf, Kempen, Germany \| ² Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany )	2023
1 year follow-up after Transcranial Pulse Stimulation in Alzheimer’s patients	Lars Wojtecki^1,2, Celine Cont^1,2,Nathalie Stute¹, Anastasia Galli¹ , Jessica Schiermeisen¹ ( ¹ Clinic for Neurology and Neurorehabilitation, Hospital zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf, Kempen, Germany \| ² Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany )	2023
Effect of Transcranial pulse stimulation for the treatment of Alzheimer’s Disease – The Spanish Experience with a control group study	Dra. Karin Freitag , Dra. Manuela C. Freitag MD, Miguel Ángel Fernández Blázquez, Dr. Ramiro Fernández Castaño MD.	2023
The efficacy and safety of TPS on young adolescents with Attention-Deficit-Hyperactivity Disorder	Teris Cheung, Bolton Chau, Kwan Hin Fong, Joyce Lam, Lok Yi Chiu, Herman Lo, Man Ho Li, Albert Martin Man Chim Li, Roland Beisteiner, Sun Lei, Benjamin K. Yee, Calvin Cheng.	2023
MRI-Tracked Transcranial Pulse Stimulation (TPS) – A New Method of Brain Stimulation to Ameliorate Deficits in Patients with Alzheimer’s Disease	Sprick U., Köhne M.: AD/PD^TM – Conference – Advances in Science & Therapy – Gothenburg / Sweden – March / April 2023	2023
TPS with the system Neurolith as a method in the treatment of the central nervous system of patients with Alzheimer’s disease	M. Ziegenbein, V. Rößner–Ruff, J.T. Michaelsen, H. Stürmann, D. Ludwig, K. Höffgen, C. Disque, O. Rosenthal, C.A. Penkov, K. Friedrich, J. Krieger, C. Hauser, D. Clark – March / April 2023	2023
Transcranial Pulse Stimulation in Alzheimer’s patients: Whom, how and where to stimulate?	Cont C., Wojtecki L.: AD/PD^TM – Conference – Advances in Science & Therapy – Gothenburg/Sweden – March / April 2023	2023
Implementing Transcranial Pulse Stimulation (TPS) at Psychiatric Department Schaffhausen, On- and Offlabel-use	Seemann O., Hechinger S., Krämer B.: AD/PD^TM – Conference – Advances in Science & Therapy – Gothenburg/Sweden – March / April 2023	2023
Revolutionary Add-on Therapeutic Concept for Alzheimer’s Disease	NeuroUp Clinic, Ankara, Turkey.	2022

Begleitende Literaturen zur Transkraniellen Pulsstimulation (TPS):

Titel	Beschreibung	Jahr
Transcranial Ultrasound Innovations Ready for Broad Clinical Application – Roland Beisteiner* and Andres M. Lozano.	Advanced Science, Progress Report, 2002026	2020
Beisteiner, R. et. al., Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy – Supporting Information.	Advanced Science, 2019, DOI: 10.1002 / advs.201902583	2019
Tyler, S. et al., Ultrasonic modulation of neuronal circuit activity.	Current opinion in neurobiology. 50, pp. 222-231	2018
Babakhanian, L. et al., Effects of low intensity focused ultrasound on liposomes containing channel proteins.	Scientific Report, 8, 17250	2018
Lin, W. et al., Protective effects of low-intensity pulsed ultrasound on aluminium-induced cerebral damage in Alzheimer‘s disease rat model.	Scientific Reports, 5, 9671	2015
Yang, P. et al., Transcranial focused ultrasound to the thalamus is associated with reduced extracellular GABA-levels in rats.	Neuropsychobiology, 65, pp. 152-160	2012
Min, P. et al., Focused ultrasound modulates the level of cortical neurotransmitters.	Journal of Imaging Systems and Technology, 21, pp.232-240	2011